Cellular therapy: shafts of light emerging for COVID-19

The COVID-19 pandemic has presented with debilitating respiratory consequences especially more pronounced in high risk individuals. Individuals with underlying systemic diseases are more prone and vulnerable to suffer severe consequences of SARS-CoV-2 infectivity. The pathophysiological changes identified cytokine storm mechanism for out setting the series of adverse clinical conditions. Thereby, associating it with high mortality rates. This warrants urgent consideration of divergent modalities such as the cellular therapy. Cellular Therapy (CT) is a new medical paradigm wherein cellular material is administered to patients for therapeutic purposes. In this regard; Stem Cells (MSCs) have yielded the most promising results among SVF; Placental Cells; NK Cells and Platelet Lysate respectively. Following the administration of the cellular therapy as per preferred route, these play pivotal role in modifying the microenvironment of the lung tissue with their distinct sets of mechanism. Evidences have shown how that their immunomodulatory action repairs and prevents lung injury which in turn improvises the lung compliance. In this review article we have discussed these emerging novel approaches and their target step serving as a ray of hope to combat severe form of COVID-19. Currently these aren’t approved for preventing or treating COVID-19 cases; however clinical trials are afoot to dispense utmost understanding in terms of efficacy and safety concern.