Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis

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Jeyaraman, Madhan and Muthu, Sathish and Jeyaraman, Naveen and Ranjan, Rajni and Jha, Saurabh Kumar and Mishra, Prabhu (2022) Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis. Indian Journal of Orthopaedics, 56 (1). pp. 1-15. ISSN 0019-5413

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Official URL: https://doi.org/10.1007/s43465-021-00439-w

Abstract

Abstract
Synovium-derived mesenchymal stromal cell (Sy-MSC) is a newer member of the mesenchymal stromal cell families. The
frst successful demonstration of the mesenchymal stromal cell from the human synovial membrane was done in 2001 and
since then its potential role for musculoskeletal regeneration has been keenly documented. The regenerative efects of Sy-
MSCs are through paracrine signaling, direct cell–cell interactions, and extracellular vehicles. Sy-MSCs possess superior chondrogenicity than other sources of mesenchymal stromal cells. This article aims to outline the advancement of synovium- derived mesenchymal stromal cells along with a specifc insight into the application for managing osteoarthritis knee.

Item Type:	Article
Subjects:	Osteoarthritis Mesenchymal Stromal Cells
Divisions:	Regenerative Medicine
Depositing User:	Mr Repository Admin
Date Deposited:	17 Oct 2023 06:14
Last Modified:	30 Jun 2024 04:56
URI:	https://ir.orthopaedicresearchgroup.com/id/eprint/98

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